Folate analogues. 33. Synthesis of folate and antifolate poly-γ-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cel

DOI: 10.1021/jm00164a038

Source and publish data:

Journal of Medicinal Chemistry p. 711 - 717 (1990)

Update date:2022-08-05

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Authors:

Abraham Abraham

Nair Nair

Kisliuk Kisliuk

Gaumont Gaumont

Galivan Galivan

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Article abstract of DOI:10.1021/jm00164a038

Representative examples of folate and antifolate poly-γ-glutamyl metabolites were synthesized via the [(9-fluorenylmethoxy)oxy]carbonyl (Fmoc) chemistry using the KH polyamide resin. Polyglutamate yields were consistently better in all cases compared to t

Full text of DOI:10.1021/jm00164a038

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