Bioorganic and Medicinal Chemistry Letters p. 4125 - 4128 (2003)
Update date:2022-08-04
Topics: Inhibitors Experimental Class Chemical Glycogen phosphorylase
Lu, Zhijian
Bohn, Joann
Bergeron, Raynald
Deng, Qiaolin
Ellsworth, Kenneth P.
Geissler, Wayne M.
Harris, Georgianna
McCann, Peggy E.
McKeever, Brian
Myers, Robert W.
Saperstein, Richard
Willoughby, Christopher A.
Yao, Jun
Chapman, Kevin
A new class of diacid analogues that binds at the AMP site not only are very potent but have ~10-fold selectivity in liver versus muscle glycogen phosphorylase (GP) in the in vitro assay. The synthesis, structure, and in vitro and in vivo biological evaluation of these liver selective glycogen phosphorylase inhibitors are discussed.
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