Journal of Medicinal Chemistry p. 1461 - 1464 (1977)
Update date:2022-08-04
Topics:
Bodanszky
Henes
Yiotakis
Said
The decapeptide derivative, L-histidyl-L-seryl-L-aspartyl-L-alanyl-L-valyl -L-phenylalanyl-L-threonyl-L-aspartyl-L-asparaginyl-L-tyrosine methyl ester, corresponding to the N-terminal sequence of both porcine and chicken VIP was synthesized in solution, by the stepwise strategy. Its pharmacological properties resemble those of VIP itself, but with a much lower potency, comparable to that of peptides with C-terminal sequences. The presence of two independent sequences carrying similar instructions was recognized in VIP.
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Doi:10.1021/ja01618a031
(1955)Doi:10.1002/ejoc.200900348
(2009)Doi:10.1016/j.jorganchem.2003.07.021
(2003)Doi:10.1016/j.ejmech.2016.03.041
(2016)Doi:10.1021/ja00460a039
(1977)Doi:10.1016/j.tet.2003.09.025
(2003)
