Journal of Medicinal Chemistry p. 1461 - 1464 (1977)
Update date:2022-08-04
Topics:
Bodanszky
Henes
Yiotakis
Said
The decapeptide derivative, L-histidyl-L-seryl-L-aspartyl-L-alanyl-L-valyl -L-phenylalanyl-L-threonyl-L-aspartyl-L-asparaginyl-L-tyrosine methyl ester, corresponding to the N-terminal sequence of both porcine and chicken VIP was synthesized in solution, by the stepwise strategy. Its pharmacological properties resemble those of VIP itself, but with a much lower potency, comparable to that of peptides with C-terminal sequences. The presence of two independent sequences carrying similar instructions was recognized in VIP.
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Doi:10.1021/ja01618a031
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