Chemical and Pharmaceutical Bulletin p. 318 - 324 (1992)
Update date:2022-09-26
Topics:
Akita
Umezawa
Matsukura
Oishi
For the purpose of carrying out smoothly enzymatic reaction of water-insoluble substrates in organic solvents, a new type of immobilized enzyme, a lipid-lipase aggregate, was developed. In order to prepare various kinds of lipid-lipase aggregates, 27 kinds of dialkyl ether-type phospholipid analogues were newly synthesized and used for the preparation of aggregates with lipase. Thus obtained lipid-lipase aggregates were found to catalyze the enantioselective hydrolysis of the (+)-α-acyloxy ester 2 much more efficiently than lipase immobilized with synthetic prepolymer (ENTP-4000) in water-saturated isopropyl ether. Namely, the reaction time became much shorter (2 to 3 d for completion as compared with 21 d) and the chemical and optical yields of the reaction products were found to be high.
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