RACEMIZATION AT PROLINE RESIDUES DURING PEPTIDE BOND FORMATION A STUDY OF DIASTEREOMERIC MIXTURES OF SYNTHETIC ALAMETHICIN FRAGMENTS BY 270 MHz 1H NMR

Article abstract of DOI:10.1016/S0040-4020(01)97953-0

The stepwise synthesis of amino terminal pentapeptide of alamethicin, Z-Aib-Pro-Aib-Ala-Aib-OMe, by the dicyclohexylcarbodiimide mediated couplings leads to extensive racemization at the Ala and Pro residues.Racemization is largely suppressed by the use o