Hetacillin (R)- and (S)-sulfoxides. Synthesis and structure-activity relationships

DOI: 10.1021/jm00200a022

Source and publish data:

Journal of Medicinal Chemistry p. 240 - 242 (1978)

Update date:2022-08-02

Topics:

Authors:

Gottestein

Kim Kim

Shih Shih

McGregor

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Article abstract of DOI:10.1021/jm00200a022

Hetacillin was oxidized with m-chloroperbenzoic acid to give the corresponding (R)- and (S)-sulfoxides. Ozonization of hetacillin not only oxidized the sulfide but caused unexpected oxidation of the imidazolidine ring to a 2H-imidazoline. The biological s

Full text of DOI:10.1021/jm00200a022

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