A New Procedure for the One-Carbon Homologation of Ketones to α-Hydroxy Aldehydes

DOI: 10.1021/jo00182a012

Source and publish data:

Journal of Organic Chemistry p. 1378 - 1382 (1984)

Update date:2022-08-05

Topics:

Authors:

Adamczyk, Maciej

Dolence, E. Kurt

Watt, David S.

Christy, M. Robert

Reibenspies, Joseph H.

Anderson, Oren P.

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Article abstract of DOI:10.1021/jo00182a012

A new, one-carbon homologation procedure for the conversion of ketones to α-hydroxy aldehydes involves two steps: (1) Darzens condensation of ketones with chloromethyl phenyl sulfone; (2) ring opening of the intermediate α,β-epoxy sulfones with hydroxide

Full text of DOI:10.1021/jo00182a012

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