KINETICS OF AMINOLYSIS FOR 1-THIO-β-D-GLUCOPYRANOSYL ESTERS OF N-ACYLALANINES

Article abstract of DOI:10.1016/S0040-4020(01)91244-X

The kinetics of aminolysis of 1-thio-β-D-glucopyranosyl esters of N-protected alanines (1) in dichloromethane at 26 deg C, by ethyl glycinate, under pseudo-first-order conditions follows the relationship k_obsd=k₂.Significant differences were obserwed in the rates of dipeptide forming aminolysis for 1-thiolesters 1a-1f, depending on N-acyl substituents and the configuration of alanine.