Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. I: Synthesis and biological properties of pyrrolo[2,3-d]pyrimidine antifolates containing tetrazole congener of glutamic acid

DOI: 10.1248/cpb.43.230

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 230 - 235 (1995)

Update date:2022-08-04

Topics:

Authors:

Itoh Itoh

Yukishige

Wajima Wajima

Ootsu Ootsu

Akimoto Akimoto

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.43.230

Either the α- or γ-carboxyl group of the glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl] benzoyl]-L-glutamic acid (1b, TNP-351) and its related compound (1a) was replaced with a ¹H-tetrazole ring, and the in

Full text of DOI:10.1248/cpb.43.230

NII-Electronic Library Service

Products guided by the article

Product name:methyl (2S)-2-(benzyloxycarbonylamino)-4-(tetrazol-5-yl)butyrate

Cas No:65882-90-8

R&D Labs maybe for 65882-90-8

Tianjin Ji Ping Jia Chemical Co., Ltd.

Contact:18622448868

Address:tianjin
hangzhou sunchem trading co., ltd.

Contact:13588470430--

Address:Room 406-407, the 4th Building, No549
Nantong Auxin Electronic Technology Co., LTD

Contact:86-513-88760026

Address:NO.5-1, Aoxin Road, Haian Hi-tech Development Zone, Jiangsu Province, China
Innua Petrochem Ltd.

Contact:+1-284-4950244

Address:Box 3069, Road Town, Tortola, British Virgin Islands
Shijiazhuang Haotian Chemical Co., Ltd.

Contact:86-311-85044374

Address:293 Donggang Road

Relevant to this article

Doi:10.1016/S0040-4039(01)83328-1
(1977)
Alkylation of 1-methyl-2-benzimidazolylacetonitrile

Doi:10.1007/BF02315179
(1998)
Doi:10.1007/BF00924570
()
α-Sulfenylation of acylsilanes and aldehydes with N- (phenylthio)succinimide

Doi:10.1016/S0040-4039(00)00515-3
(2000)
Unsymmetrical Disulfides Synthesis via Cs₂CO₃-Catalyzed Three-Component Reaction in Water

Doi:10.1002/adsc.202000851
(2020)
Reversal of the apparent regiospecificity of NAD(P)H-dependent hydride transfer: The properties of the difluoromethylene group, a carbonyl mimic

Doi:10.1021/ja021487+
(2003)

Article Doi