Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. I: Synthesis and biological properties of pyrrolo[2,3-d]pyrimidine antifolates containing tetrazole congener of glutamic acid

DOI: 10.1248/cpb.43.230

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 230 - 235 (1995)

Update date:2022-08-04

Topics:

Authors:

Itoh Itoh

Yukishige

Wajima Wajima

Ootsu Ootsu

Akimoto Akimoto

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Article abstract of DOI:10.1248/cpb.43.230

Either the α- or γ-carboxyl group of the glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl] benzoyl]-L-glutamic acid (1b, TNP-351) and its related compound (1a) was replaced with a ¹H-tetrazole ring, and the in

Full text of DOI:10.1248/cpb.43.230

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