Fluorescence characteristics of azaperone and of an azaperone mononitrogen oxide

Article abstract of DOI:10.1002/jps.2600661239

The structure elucidation of the compound isolated after peroxide treatment of azaperone is described. A mononitrogen oxide was formed at the piperazine N₁ atom after reaction with excess hydrogen peroxide. The fluorescence characteristics of the derivative were examined and compared with the native fluorescence capacities of the azaperone base; both were identical, depending on the solvent nature. The phenomenon is explained by the fact that the fluorescent properties of the azaperone molecule are principally produced by its ortho-nitrogen substituted pyridine nucleus.