PRACTICAL PROCEDURE FOR EPIMERIZATION OF 7α-AMINO-1-OXACEPHEMS TO 7β-AMINO EPIMERS

DOI: 10.1016/S0040-4039(01)80812-1

Source and publish data:

Tetrahedron Letters p. 339 - 342 (1985)

Update date:2022-08-05

Topics: Epimerization Reaction Conditions Analytical Techniques Chemical Reagents Experimental procedure

Authors:

Aoki, T.

Haga, N.

Sendo, Y.

Konoike, T.

Yoshioka, M.

Nagata, W.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(01)80812-1

7α-Amino-1-oxacephems can be epimerized to their 7β-amino epimers by treatment with chloral to give Schiff bases, followed by dehydrochlorination with Huenig base, borohydride reduction, and hydrolysis.

Full text of DOI:10.1016/S0040-4039(01)80812-1

Products guided by the article

Product name:(6R,7R)-7-Amino-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Cas No:66511-39-5

R&D Labs maybe for 66511-39-5

ALPHA PHARMACEUTICAL CO，LTD JIANGSU

Contact:+86-527-84829968,+86-527-84829998

Address:suqian city
Shanghai Hanhong Scientific Co.,Ltd.

website:http://www.chemvia.com

Contact:+86-21-64541543,54280654,13918533501

Address:Jiachuan Road 245
Hubei Lingsheng Pharmaceuticals Co., Ltd.

Contact:+86-0710-3538058

Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
HANGZHOU ICH BIOFARM CO.,LTD

Contact:+86-571-28186845

Address:Room 1224,Eastcom Mansion,398 Wensan Road,Hangzhou,310013 China

Relevant to this article

BF₃-mediated oxidative cross-coupling of pyridines with alkynyllithium reagents and further reductive functionalizations of the pyridine scaffold

Doi:10.1055/s-0033-1341235
(2014)
Crystal-to-Crystal Synthesis of Photocatalytic Metal–Organic Frameworks for Visible-Light Reductive Coupling and Mechanistic Investigations

Doi:10.1002/cssc.202000465
(2020)
Synthesis of antitumor 6-alkylidenepenicillanate sulfones and related 3-alkylidene-2-azetidinones

Doi:10.1016/j.bmcl.2003.09.078
(2004)
(3R,4S)-3,4,5-Trihydroxy-4-methylpentylphosphonic acid, an isosteric phosphonate analogue of 2-C-methyl-D-erythritol 4-phosphate, a key intermediate in the new pathway for isoprenoid biosynthesis

Doi:10.1016/j.tetlet.2003.11.001
(2004)
Syntheses of nitrogen-containing heterocyclic compounds. XXVIII. The Reissert reaction of 4,6-phenanthroline

Doi:10.1248/cpb.26.350
(1978)
Synthesis and antibacterial activity of substituted thiosemicarbazides and of 1,3,4-thiadiazole or 1,2,4-triazole derivatives

Doi:10.1080/10426500500269851
(2006)

Article Doi