PRACTICAL PROCEDURE FOR EPIMERIZATION OF 7α-AMINO-1-OXACEPHEMS TO 7β-AMINO EPIMERS

DOI: 10.1016/S0040-4039(01)80812-1

Source and publish data:

Tetrahedron Letters p. 339 - 342 (1985)

Update date:2022-08-05

Topics: Epimerization Reaction Conditions Analytical Techniques Chemical Reagents Experimental procedure

Authors:

Aoki, T.

Haga, N.

Sendo, Y.

Konoike, T.

Yoshioka, M.

Nagata, W.

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Article abstract of DOI:10.1016/S0040-4039(01)80812-1

7α-Amino-1-oxacephems can be epimerized to their 7β-amino epimers by treatment with chloral to give Schiff bases, followed by dehydrochlorination with Huenig base, borohydride reduction, and hydrolysis.

Full text of DOI:10.1016/S0040-4039(01)80812-1

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