Benzocyclization of 2,4-Hexadienoic Acids. Synthesis of (R)-(-)-Curcuphenol Acetate

Article abstract of DOI:10.1055/s-1987-27905

A simple and general benzocyclization sequence, useful in the conversion of α-methylene ketones/aldehydes 1a-f to phenolic acetates 6a-g via the dienoic acids 5a-g is presented.The technique has provided a new route to the terpenoids, thymol acetate (6f) and (R)-(-)-curcuphenol acetate (6g).