Diastereoselective alkynylation of chiral non-racemic oxazolidines with mixed organoaluminum compounds

DOI: 10.1016/S0040-4039(99)00328-7

Source and publish data:

Tetrahedron Letters p. 2935 - 2938 (1999)

Update date:2022-07-30

Topics:

Authors:

Blanchet, Jerome

Bonin, Martine

Chiaroni, Angele

Micouin, Laurent

Riche, Claude

Husson, Henri-Philippe

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Article abstract of DOI:10.1016/S0040-4039(99)00328-7

A new efficient and scalable route to chiral non-racemic α-substituted propargylamines is described. The reaction pathway consists of the diastereoselective addition of mixed alkynylaluminum reagents to oxazolidines derived from R- (-)-phenylglycinol.

Full text of DOI:10.1016/S0040-4039(99)00328-7

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