Competitive inhibition of a glutamate carboxypeptidase by phosphonamidothionate derivatives of glutamic acid

DOI: 10.1016/S0960-894X(99)00198-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1415 - 1418 (1999)

Update date:2022-08-05

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Authors:

Rodriguez, Chester E.

Lu, Haiyan

Dinh, Trang T.

Mlodnosky, Karyn L.

Dastgah, Azar

Lam, Vinh Q.

Nichols, C. Blake

Berkman, Clifford E.

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Article abstract of DOI:10.1016/S0960-894X(99)00198-5

Several N-thiophosphonyl-glutamates were found to be potent competitive inhibitors of a zinc-dependent glutamyl hydrolase, carboxypeptidase G (CPG). Weak inhibition exhibited by an analogous N-phosphonyl-glutamate suggests that the enhanced potency of the

Full text of DOI:10.1016/S0960-894X(99)00198-5

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