Synthesis of daunorubicin-14-14C and adriamycin-14-14C

DOI: 10.1002/jlcr.2580140115

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 111 - 117,113,115 (1978)

Update date:2022-07-30

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Authors:

Chen Chen

Tan Fong

Fujiwara

et al. et al.

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Article abstract of DOI:10.1002/jlcr.2580140115

Reaction of adriamycinone with excess ¹⁴CH₃MgI and periodate cleavage of the resulting glycol (5) affords daunomycinone-14-¹⁴C (6). Bromination and hydrolysis of 6 gives adriamycinone-14-¹⁴C (8). Coupling of 6 a

Full text of DOI:10.1002/jlcr.2580140115

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