Bioorganic and Medicinal Chemistry Letters p. 787 - 791 (2005)
Update date:2022-08-02
Topics:
Batt, Douglas G.
Houghton, Gregory C.
Roderick, John
Santella III, Joseph B.
Wacker, Dean A.
Welch, Patricia K.
Orlovsky, Yevgeniya I.
Wadman, Eric A.
Trzaskos, James M.
Davies, Paul
Decicco, Carl P.
Carter, Percy H.
The synthesis and structure-activity relationships of N- arylalkylpiperidylmethyl ureas as antagonists of the CC chemokine receptor-3 (CCR3) are presented. These compounds displayed potent binding to the receptor as well as functional antagonism of eotaxin-elicited effects on eosinophils.
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