Journal of Pharmaceutical Sciences p. 1154 - 1157 (1978)
Update date:2022-08-02
Topics: Solubility Aromatic ring Functional Groups Metabolism
Newton
Structure-toxicity relationships of iodinated aromatic carbonates, carbamates, and esters are presented. The approximate lethal dose of intraperitoneal injections in mice was used for toxicity determinations. Increasing the alkyl portion of the molecules reduced toxicity. m-Amino and m-acetamido groups also reduced toxicity. Carbonates were preferred X-ray contrast agents because of their low viscosity and more rapid elimination.
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