Mg-promoted reductive cross coupling of carbonyl compounds with trimethylsilyl chloride

Article abstract of DOI:10.1246/cl.1995.829

Mg-promoted cross-coupling of aromatic carbonyl compounds with trimethylsilyl chloride (TMSCl) in DMF at room temperature brought about reductive carbon-silicon bond formation to give the corresponding α-trimethylsilylalkyl trimethylsilyl ethers selectively in good yields.The reaction may be initiated through electron transfer from Mg metal to the carbonyl compounds.