Bioorganic and medicinal chemistry letters p. 2847 - 2850 (2001)
Update date:2022-08-02
Topics:
Lavoie
Bouchain
Frechette
Woo
Abou-Khalil
Leit
Fournel
Yan
Trachy-Bourget
Beaulieu
Li
Besterman
Delorme
Histone deacetylase inhibitors (HDACs) have emerged as a novel class of antiproliferative agents. Utilizing structure-based design, the synthesis of a series of sulfonamide hydroxamic acids is described. Further optimization of this series by substitution of the terminal aromatic ring yielded HDAC inhibitors with good in vitro and in vivo activities.
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