Organic Letters p. 3920 - 3923 (2012)
Update date:2022-08-04
Topics:
Ingham, Richard J.
Riva, Elena
Nikbin, Nikzad
Baxendale, Ian R.
Ley, Steven V.
The development of a monolith-supported synthetic procedure is reported, taking advantage of flow processing and the superior flow characteristics of monolithic reagents over gel-phase beads, to allow facile access to an important family of 2-aminopyrimidine derivatives. The process has been successfully applied to a key precursor on route to Imatinib (Ar = 3-pyridyl, R1 = 2-methyl-5-nitrobenzyl, R2 = H).
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Doi:10.1246/bcsj.52.1225
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