Phosphorus, Sulfur and Silicon and the Related Elements p. 2415 - 2429 (2003)
Update date:2022-08-04
Topics:
Aly
3-(4-Thioxo-3,4-dihydroquinazolin-2-yl)acrylic acid 1 proved to be a convenient precursor for the synthesis of novel polyfunctional quinazoline derivatives of pharmaceutical interest via its treatment with some π-deficient compounds such as phenyl isocyanate and phenyl isothiocyanate. Also, S- and N-glucosidation of quinazoline has been achieved by treatment of 1 with glucopyranosyl bromide in alkaline medium. The behavior of 1 toward acrylonitrile (under Michael reaction condition), paraformaldehyde in the presence of secondary amines (under Mannich reaction condition) and sodium azide were investigated. Moreover, the peptidyl derivatives of quinazoline have been synthesized by condensation of 1 with α-amino acids via different routes. Some of the newly synthesized products were tested for their antimicrobial activities. The structure assignments are based on the analytical and spectroscopic results.
View MoreNEW FORTUNE INDUSTRIAL CO.,LTD.
website:http://newfortune.lookchem.com/
Contact:+86-25-8645-9456
Address:C4-105 GREEN ISLAND FLOWER TOWN
Contact:+86-571-86491666
Address:SHI XIANG ROAD
website:http://www.eastarchem.com/
Contact:1-800-898-2436
Address:1215 K Street, STE 1700
Yangling Ciyuan biotech Co., Ltd.
Contact:86-15802970736
Address:2-1804, International Park Mansion, No.2, South Fengdeng Road, Lianhu District
Global United Biotechnology Inc.
Contact:+86-21-61618568
Address:Room 309, Building 6, NO.135, Jinyu Road, Pudong
Doi:10.1021/jo01300a031
(1980)Doi:10.1021/ja039336+
(2004)Doi:10.1021/ja039795a
(2004)Doi:10.1021/ol049649p
(2004)Doi:10.1016/j.bmcl.2014.07.074
(2014)Doi:10.1002/chem.201904025
(2019)