Chemical Communications p. 12814 - 12817 (2017)
Update date:2022-08-05
Topics:
Castellani, Beatrice
Diamanti, Eleonora
Pizzirani, Daniela
Tardia, Piero
Maccesi, Martina
Realini, Natalia
Magotti, Paola
Garau, Gianpiero
Bakkum, Thomas
Rivara, Silvia
Mor, Marco
Piomelli, Daniele
N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is a membrane-associated zinc enzyme that catalyzes the hydrolysis of N-acylphosphatidylethanolamines (NAPEs) into fatty acid ethanolamides (FAEs). Here, we describe the identification of the first small-molecule NAPE-PLD inhibitor, the quinazoline sulfonamide derivative 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide, ARN19874.
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