Synthesis of 8-Bromoflavone and Its Buchwald-Hartwig Reaction with Amines

Article abstract of DOI:10.1055/s-0035-1560325

Simple and convenient synthesis of 8-bromoflavone was achieved, starting from 2-bromophenol through 3′-bromo-2′-hydroxyacetophenone whose preparation was managed to be solved by optimized Fries rearrangement. The Buchwald-Hartwig reaction of 8-bromoflavone with different type of primary and secondary amines was carried out.