Lithiated dimethoxymethyl diphenyl phosphine oxide, a versatile formiate carbanion equivalent

DOI: 10.1055/s-2002-20486

Source and publish data:

Synlett p. 525 - 527 (2002)

Update date:2022-08-04

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Authors:

Monenschein, Holger

Brünjes, Marco

Kirschning, Andreas

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Article abstract of DOI:10.1055/s-2002-20486

Aldehydes are homologated to the corresponding α-hydroxy methyl esters using lithiated dimethoxymethyl diphenyl phosphine oxide. The primary addition product of this Horner-Wittig process collapses to the corresponding α-hydroxy ester under proton-catalyzed conditions.

Full text of DOI:10.1055/s-2002-20486

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