Journal of labelled compounds and radiopharmaceuticals p. 611 - 615,613,614 (1978)
Update date:2022-08-02
Topics:
Greenaway
Whatley
The preparation of creatine-15N monohydrate from glycine-15N with the isolation of sarcosine-15N as an intermediate is described. Glycine- 15N (97.3 atom% 15N) is converted to benzenesulphonyl glycine- 15N, which is methylated to give benzenesulphonyl sarcosine-15N. The latter is hydrolysed to sarcosine-15N, which is isolated by ion exchange chromatography. Sarcosine-15N is converted to creatine-15N monohydrate by reaction with cyanamide in aqueous solution in the presence of sodium chloride and catalytic amounts of ammonium ammoniu hydroxide-14N. The creatinine-15N monohydrate precipitated from the above reaction mix is recrystablized from boiling water. The yield of sarcosine-15N from glycine-15N is 78% of theory and that of recrystallized creatine-15N monohydrate from glycine-15N is 59% of theory.
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