Pyridazinones as selective cyclooxygenase-2 inhibitors

DOI: 10.1016/S0960-894X(02)01045-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 597 - 600 (2003)

Update date:2022-08-05

Topics:

Authors:

Li, Chun Sing

Brideau, Christine

Chan, Chi Chung

Savoie, Chantal

Claveau, David

Charleson, Stella

Gordon, Robert

Greig, Gillian

Gauthier, Jacques Yves

Lau, Cheuk K.

Riendeau, Denis

Therien, Michel

Wong, Elizabeth

Prasit, Petpiboon

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Article abstract of DOI:10.1016/S0960-894X(02)01045-4

Pyridazinone was found to be an excellent core template for selective COX-2 inhibitors. Two potent, selective and orally active COX-2 inhibitors, which were highly efficacious in rat paw edema and rat pyresis models, have been obtained.

Full text of DOI:10.1016/S0960-894X(02)01045-4

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