An expeditious synthesis of Z-3-alkylidene isoindolinones via combined palladium catalysed and Friedel-Crafts reactions

DOI: 10.1016/S0040-4039(97)01626-2

Source and publish data:

Tetrahedron Letters p. 6937 - 6940 (1997)

Update date:2022-07-30

Topics:

Authors:

Kundu, Nitya G.

Khan, M. Wahab

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Article abstract of DOI:10.1016/S0040-4039(97)01626-2

N-Aryl(or, alkyl)-2-iodobenzamides underwent palladium-catalysed reaction with (trimethylsilyl)acetylene to form N-substituted-2-(trimethylsilyl)ethynyl benzamides, which on further Friedel-Crafts acylation and cyclisation yielded Z-3-alkylidene isoindolin-1-ones in a completely regio- and stereoselective manner.

Full text of DOI:10.1016/S0040-4039(97)01626-2

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Product name:2-(4-Methoxy-phenyl)-3-[2-oxo-2-phenyl-eth-(Z)-ylidene]-2,3-dihydro-isoindol-1-one

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