
Green Chemistry p. 2775 - 2780 (2018)
Update date:2022-08-04
Topics:
Wang, Dong
Li, Linna
Feng, Hairong
Sun, Hua
Almeida-Veloso, Fabrice
Charavin, Marine
Yu, Peng
Désaubry, Laurent
An efficient synthesis of fully substituted 2,3-dihydropyrroles has been achieved in one step through the three-component reaction of amines, aromatic aldehydes and α-ketoamides. This atom-economical and catalyst-free reaction is highly stereoselective and generates underexplored heterocycles in a single step. These compounds were examined in an enzymatic assay that led to the identification of potent α-glucosidase inhibitors, thereby demonstrating the utility of this novel methodology in medicinal chemistry.
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Doi:10.1021/ja0782955
(2008)Doi:10.1039/b910239f
(2009)Doi:10.1248/cpb.27.1
(1979)Doi:10.1021/ja01105a028
(1953)Doi:10.1002/chem.201705810
(2018)Doi:10.1021/jo01328a028
(1979)