Journal of Medicinal Chemistry p. 742 - 748 (1981)
Update date:2022-08-04
Topics:
Klaubert, Dieter H.
Sellstedt, John H.
Guinosso, Charles J.
Capetola, Robert J.
Bell, Stanley C.
A series of N-(2-cyano-substituted-phenyl)oxamates was prepared by acylation of the appropriate anthranilonitrile with ethyloxalyl chloride.Hydrolysis with sodium hydroxide gave the corresponding oxamic acid sodium salts.These compounds were extremely potent when tested in the rat passive cutaneous anaphylaxis (PCA assay either by the ip or the po route of administration).One of the sodium salts, <<2-cyano-3-(methylamino)phenyl>oxoacetic acid sodium salt (11a, Wy-41 195), has ED50 value of 0.07 mg/kg po and has been selected for further evaluation.
View MoreContact:+86-15995924277
Address:WuZhongOu suzhou new south road 89
NanJing Rate Biochemicals CO., LTD
Contact:+86-25-84931986
Address:NO. 1 Hongjing Road,Jiangning Science Park,Nanjing,China
Hangzhou Share Chemical Co., Ltd(expird)
Contact:+86-57187093700
Address:Hang Xing Road
AstaTech ( Chengdu) BioPharmaceutical Corp.
website:http://www.astabiochem.cn/
Contact:+86-15198215156-15198215156
Address:SICHUAN CHENGDU
Zhejiang Haizhou Pharmaceutical Co., Ltd.
website:https://www.haizhoupharma.com/
Contact:+86-576-88221016
Address:No. 19, Donghai 5th Avenue, Yanhai Industrial Zone, Linhai, Zhejiang, China
Doi:10.1021/ja00210a084
(1988)Doi:10.1515/znb-2008-0514
(2008)Doi:10.1021/jo00237a001
(1988)Doi:10.1021/ml300090x
(2012)Doi:10.1246/cl.1987.809
(1987)Doi:10.1021/ja00194a044
(1989)