Identification of 4-(1H-Imidazol-4(5)-ylmethyl)pyridine (Immethridine) as a Novel, Potent, and Highly Selective Histamine H3 Receptor Agonist

DOI: 10.1021/jm049932u

Source and publish data:

Journal of Medicinal Chemistry p. 2414 - 2417 (2004)

Update date:2022-08-03

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Authors:

Kitbunnadaj, Ruengwit

Zuiderveld, Obbe P.

Christophe, Bernard

Hulscher, Saskia

Menge, Wiro M. P. B.

Gelens, Edith

Snip, Erwin

Bakker, Remko A.

Celanire, Sylvain

Gillard, Michel

Talaga, Patrice

Timmerman, Henk

Leurs, Rob

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Article abstract of DOI:10.1021/jm049932u

In this study, the piperidine ring of immepip and its analogues was replaced by a rigid heterocyclic pyridine ring. Many compounds in the series exhibit high affinity and agonist activity at the human histamine H₃ receptor. Particularly, the 4-

Full text of DOI:10.1021/jm049932u

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