Tetrahedron p. 10253 - 10258 (1995)
Update date:2022-08-04
Topics:
Victory, Pedro
Cirujeda, Joan
Vidal-Ferran, Anton
The cyclization of 2-cyanamino-4,6-diphenylpyridine-3-carbonitrile promoted by hydrogen halides takes place regiospecifically leading in all the cases to the 4-amino-2-halogen substituted pyrido<2,3-d>pyrimidine.This procedure completes a flexible and straightforward approach to aromatic pyrido<2,3-d>pyrimidines from acyclic precursors.
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