Two Step Synthesis of Pyridopyrimidines from Acyclic Precursors. Cyclization of 2-Cyanamino-4,6-diphenylpyridine-3-carbonitrile by Hydrogen Halides

DOI: 10.1016/0040-4020(95)00585-V

Source and publish data:

Tetrahedron p. 10253 - 10258 (1995)

Update date:2022-08-04

Topics:

Authors:

Victory, Pedro

Cirujeda, Joan

Vidal-Ferran, Anton

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Article abstract of DOI:10.1016/0040-4020(95)00585-V

The cyclization of 2-cyanamino-4,6-diphenylpyridine-3-carbonitrile promoted by hydrogen halides takes place regiospecifically leading in all the cases to the 4-amino-2-halogen substituted pyrido<2,3-d>pyrimidine.This procedure completes a flexible and straightforward approach to aromatic pyrido<2,3-d>pyrimidines from acyclic precursors.

Full text of DOI:10.1016/0040-4020(95)00585-V

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