Tetrahedron p. 1001 - 1012 (1991)
Update date:2022-08-03
Topics:
Dubois, Joelle
Foures, Christine
Bory, Sonia
Falcou, Serge
Gaudry, Michel
Marquet, Andree
Schemes for the synthesis of 5,5'-dihydroxyleucine 3 and its 4-fluoro analog 7 involving the condensation of a suitable 'aminoacid moiety' with 2,2-dimethyl-5-iodomethyl-1,3-dioxane 15D or its fluoro analog 27A were tested.The anion of the ethyl N-diphenylmethylene-glycinate 25 gave better yields of 3 than the classical anion of diethyl acetamidomalonate.This strategy could not be successfully applied to the synthesis of 7, which could be prepared by reduction of a suitably protected 4-fluoro-4-carboxyglutamate with BMS.
View MoreContact:+86-577-65618087-605
Address:Room 402, Unit 4 Xinhu Bldg. Waitan Ruian City, Zhejiang China.
Zhejiang Quzhou Jiancheng Silicone Co., Ltd.(Shanghai Jiancheng Industial and Trade Co, Ltd)
Contact:18957018777 +86-570-3888777
Address:The company production base address： Quzhou City, Zhejiang Province high-tech industrial park Nianhua Road 37
TAIXING BEST NEW MATERIALS CO., LTD
Contact:0523-87998158;
Address:No.18 Zhonggang Road，Taixing City ，Jiangsu , China
Contact:0086-29-89196322
Address:North of the Fifth Keji Road, Hi-Tech Industrial Zone, Xi'an City, Shaanxi Province, China
Liao Cheng All Win Chemicals Co.,LTD
Contact:86+0635-2991582
Address:Room 402,Unit 1,No.27 building.Zhong tong shi dai haoyuan,liaocheng city,Shan dong Province.China
Doi:10.1002/hlca.19790620216
(1979)Doi:10.1016/S0960-894X(98)00167-X
(1998)Doi:10.1016/j.poly.2017.01.018
(2017)Doi:10.1021/ol5030037
(2014)Doi:10.1016/S0040-4020(97)10340-4
(1998)Doi:10.1021/jo050077b
(2005)
