Bioorganic and Medicinal Chemistry Letters p. 3664 - 3668 (2009)
Update date:2022-08-04
Topics:
Charrier, Nicolas
Clarke, Brian
Cutler, Leanne
Demont, Emmanuel
Dingwall, Colin
Dunsdon, Rachel
Hawkins, Julie
Howes, Colin
Hubbard, Julia
Hussain, Ishrut
Maile, Graham
Matico, Rosalie
Mosley, Julie
Naylor, Alan
O'Brien, Alistair
Redshaw, Sally
Rowland, Paul
Soleil, Virginie
Smith, Kathrine J.
Sweitzer, Sharon
Theobald, Pam
Vesey, David
Walter, Daryl S.
Wayne, Gareth
Inhibition of the aspartyl protease BACE-1 has the potential to deliver a disease-modifying therapy for Alzheimer's disease. We have recently disclosed a series of transition-state mimetic BACE-1 inhibitors showing nanomolar potency in cell-based assays.
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(1979)
