2,3-Dihydrobenzofuran-2-ones: A New Class of Highly Potent Antiflammatory Agents

DOI: 10.1021/jm00144a019

Source and publish data:

Journal of Medicinal Chemistry p. 1465 - 1471 (1981)

Update date:2022-08-04

Topics:

Authors:

Closse, Annemarie

Haefliger, Walter

Hauser, Daniel

Gubler, Hans Ulrich

Dewald, Beatrice

Baggiolini, Marco

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Article abstract of DOI:10.1021/jm00144a019

A series of 2,3-dihydrobenzofuran-2-one analogues of the mold metabolite wortmannin, which is a powerful antiimflammatory compound, was synthesized.Most of these compounds were tested for their ability to inhibit the carrageenin paw edema and the adjuvant

Full text of DOI:10.1021/jm00144a019

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