Short asymmetric syntheses of homoallylic, homopropargylic and allenic silylated primary amines

Article abstract of DOI:10.1016/j.tetlet.2004.03.066

Amino alcohols derived from phenylglycinol and having vinyl-, alkynyl- or allenylsilane moieties were transformed in the corresponding primary amines in two steps: oxidative cleavage of phenylglycinol and transimination with phenylhydrazine. This methodology gave general access to enantiomerically enriched amines without loss of enantioselectivity.