Journal of medicinal chemistry p. 566 - 569 (1980)
Update date:2022-07-30
Topics:
Bodor
Kaminski
A class of soft alkylating compounds as potential anticancer agents was developed. The first examples include alpha-halo esters of various carboxylic acids. A new method for quantitative evaluation of the alkylating reactivity was developed, using a competitive alkylation reactivity was developed, using a competitive alkylation reaction, followed by NMR analysis of the reaction mixture. The method is sensitive and reproducible. One of the two selected soft alkylating agents, chloromethyl hexanoate, was found to have anticancer activity.
View MoreContact:+86-21-54391580
Address:Room 502,No.65,Lane 2388 Hongxin Road,Shanghai,China
Xi'an Unique Electronic and Chemical Co., Ltd.
Contact:+86-029-88238008
Address:1703# B BUILDING WEST ELECTRONIC ZONE, XI'AN, CHINA
Huangshan Violet Biological Technology Co., Ltd
Contact:+86-559-2335676
Address:16-201 JinShanYuan,JiangNan New City,TunXi District,HuangShan City,AnHui Province,China
Shanghai Hanhong Scientific Co.,Ltd.
website:http://www.chemvia.com
Contact:+86-21-64541543,54280654,13918533501
Address:Jiachuan Road 245
Shenzhen HwaGen Pharmaceutical Co., Ltd
website:http://www.rafflespt.com
Contact:+86-752-5538396
Address:Guangdong Huizhou China
Doi:10.1021/acs.joc.6b01240
(2016)Doi:10.1039/P19800001879
(1980)Doi:10.1039/b401447b
(2004)Doi:10.1016/j.ultsonch.2013.05.010
(2014)Doi:10.1016/0040-4039(93)88007-6
(1992)Doi:10.1021/jo501815y
(2014)
