Bioorganic and Medicinal Chemistry Letters p. 2543 - 2548 (2006)
Update date:2022-08-04
Topics:
Barril, Xavier
Beswick, Mandy C.
Collier, Adam
Drysdale, Martin J.
Dymock, Brian W.
Fink, Alexandra
Grant, Kate
Howes, Robert
Jordan, Allan M.
Massey, Andrew
Surgenor, Allan
Wayne, Joanne
Workman, Paul
Wright, Lisa
Novel piperazinyl, morpholino and piperidyl derivatives of the pyrazole-based Hsp90 inhibitor CCT018159 are described. Structure-activity relationships have been elucidated by X-ray co-crystal analysis of the new compounds bound to the N-terminal domain o
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