Oxytocin and Lysine-vasopressin with N5,N5-Dialkylglutamine in the 4 Position: Effect of Introducing Sterically Hindered Groups into the Hydrophilic Cluster of Neurohypophyseal Hormones

DOI: 10.1021/jm00176a020

Source and publish data:

Journal of Medicinal Chemistry p. 213 - 217 (1980)

Update date:2022-08-05

Topics:

Authors:

Stahl, Glenn L.

Smith, Clark W.

Walter, Roderich

Tsegenidis, theodor

Stavropoulos, George

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00176a020

The synthesis and pharmacological potencies of oxytocin and lysine-vasopressin analogues are reported in which the N⁵-amide of their glutaminyl residues are dialkylated.These analogues have been studied as an ongoing exploration of the biologic

Full text of DOI:10.1021/jm00176a020

Products guided by the article

Product name:<4-(N⁵,N⁵-dimethylglutamine)>oxytocin

Cas No:72449-56-0

R&D Labs maybe for 72449-56-0

Shenzhen HwaGen Pharmaceutical Co., Ltd

website:http://www.rafflespt.com

Contact:+86-752-5538396

Address:Guangdong Huizhou China
henan victory industry co.ltd

Contact:86-371-63655023

Address:No.85,jinshui road,zhengzhou,China
Synchem Pharma Co.,Ltd(expird)

Contact:+0086-21-61984905-1

Address:Building 60,Zimian Park, LongYang industrial Area, 1515Nong，Yuandong Road Fengxian District, Shanghai ,China
Hangzhou Yingshanhua Pigment Chemicals Co.,Ltd.

Contact:+86-0150-58101658

Address:Nanyang Economic DevelopmentZong,Xiaoshan,Hangzhou,China
Shanghai Gsyn Chemical Co.,Ltd.

Contact:86-021-67158290

Address:86-021-67158291

Relevant to this article

Synthesis of 2H-Isoindole-4,7-diones by 1,3-Dipolar Addition of Oxazolium 5-Oxides to 1,4-Quinones

Doi:10.1021/jo01295a006
(1980)
Structure-Activity Relationship Studies of a Series of Semisynthetic Lipopeptides Leading to the Discovery of Surotomycin, a Novel Cyclic Lipopeptide Being Developed for the Treatment of Clostridium difficile -Associated Diarrhea

Doi:10.1021/acs.jmedchem.5b00366
(2015)
Doi:10.1007/BF00473832
()
Scalable synthesis of multi-substituted aryl-phosphonates: Exploring the limits of isoretical expansion and the synthesis of new triazene-based phosphonates

Doi:10.1080/10426507.2019.1673750
(2020)
Two-Photon Probes for Lysosomes and Mitochondria: Simultaneous Detection of Lysosomes and Mitochondria in Live Tissues by Dual-Color Two-Photon Microscopy Imaging

Doi:10.1002/asia.201500314
(2015)
One-step Synthesis of Functionalized Dioxaspiro<4,5>decanes from β-Phenylsulfonyl Dihydrofurans and γ-Lactones

Doi:10.1016/0040-4039(94)85041-0
(1994)

Article Doi