Oxytocin and Lysine-vasopressin with N5,N5-Dialkylglutamine in the 4 Position: Effect of Introducing Sterically Hindered Groups into the Hydrophilic Cluster of Neurohypophyseal Hormones

Article abstract of DOI:10.1021/jm00176a020

The synthesis and pharmacological potencies of oxytocin and lysine-vasopressin analogues are reported in which the N⁵-amide of their glutaminyl residues are dialkylated.These analogues have been studied as an ongoing exploration of the biologic