Inhibitors of Polyamine Biosynthesis. 8. Irreversible Inhibition of Mammalian S-Adenosyl-L-methionine Decarboxylase by Substrate Analogues

Article abstract of DOI:10.1021/jm00176a004

Analogues of S-adenosyl-L-methionine (1) were synthesized and evaluated as inhibitors of the enzyme S-adenosyl-L-methionine decarboxylase from rat liver.The compounds synthesized were S-(5'-deoxy-5'-adenosyl)-(+/-)-2-methylhomocysteine (10), S-(5'-deoxy-5