Convenient Synthesis of 10-Deazaaminopterin via a Pteridine Ylide

DOI: 10.1021/jm00177a022

Source and publish data:

Journal of Medicinal Chemistry p. 320 - 321 (1980)

Update date:2022-08-03

Topics:

Authors:

Piper, James R.

Montgomery, John A.

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Article abstract of DOI:10.1021/jm00177a022

10-Deazaaminopterin, a potential antitumor agent now undergoing clinical trials, has been synthesized by a new approach involving the Wittig reaction.The ylide obtained by reaction of 6-(bromomethyl)-2,4-pteridinediamine with triphenylphosphine in Me2NAc,

Full text of DOI:10.1021/jm00177a022

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