Short and efficient synthesis of (R)-4-hydroxy-4-methyl cyclohexenone

Article abstract of DOI:10.1016/0040-4039(95)00581-V

The two steps asymmetric synthesis of the enantiomerically pure (R)-4-hydroxy-4-methylcyclohex-2-en-1-one is reported in a 70% overall yield. The highly stereoselective addition of AlMe₃/ZnBr₂ to [2S,(S)R]-4,4-ethylenedioxy-2-p-tolyl