Heterocyclic Prostaglandin Analogues. Part 3. The Relationship of Configuration to Biological Activity for Some Hydantoin Prostanglandin Analogues

DOI: 10.1039/P19810000706

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 706 - 711 (1981)

Update date:2022-09-26

Topics:

Authors:

Brockwell, Michael A.

Caldwell, A. Gordon

Whittaker, Norman

Begley, Michael J.

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Article abstract of DOI:10.1039/P19810000706

The enantiomers of the two diastereomers of 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)hydantoin have been synthesised.Potent inhibition of platelet aggregation in this series is associated with the configuration corresponding to that in the natural inhibitors, such as prostaglandins E₁ and D₂.

Full text of DOI:10.1039/P19810000706

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