The Use of Grignard Reagents in the Synthesis of Carbohydrates. II. The Cleavage of Acetal Protecting Groups in Sugar Derivatives

Article abstract of DOI:10.1246/bcsj.53.230

The selective reaction of acetal protecting groups in sugars with Grignard reagents is described.The treatment of 1,2:5,6-di-O-cyclohexylidene-α-D-glucofuranose (1) with methylmagnesium iodide in benzene-ether at about 85 deg C gave 1,2-O-cyclohexylidene-