Welcome to LookChem.com Sign In|Join Free

Article Doi

Efficient asymmetric hydrogenation of β- and γ-amino ketone derivatives leading to practical synthesis of fluoxetine and eprozinol

DOI: 10.1248/cpb.43.748

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 748 - 753 (1995)

Update date:2022-08-05

Topics:

Authors:

SakurabaSakuraba

AchiwaAchiwa

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.43.748

N-(Methylcarbamoyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)me thyl]pyrrolidine (MCCPM)- and N-(tert-butoxycarbonyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphin o)methyl]pyrrolidine (BCPM)-rhodium(I) complexes were efficient catalysts for asymmetric hydrogenations of β- and γ-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient syntheses of fluoxetine and eprozinol from intermediate optically active amino alcohols.

View More

Full text of DOI:10.1248/cpb.43.748

NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  
NII-Electronic Library Service  

Products guided by the article

Product name:4-(N-benzyl-N-methylamino)butyrophenone

Cas No:735240-08-1

735240-08-1

R&D Labs maybe for 735240-08-1

Relevant to this article

Hot Product