NEW SYNTHETIC APPROACH TO PYRANONAPHTHOQUINONE ANTIBIOTICS, (+/-)-NANAOMYCIN A AND (+/-)-DEOXYFRENOLICIN

DOI: 10.1246/cl.1982.609

Source and publish data:

Chemistry Letters p. 609 - 612 (1982)

Update date:2022-08-05

Topics:

Authors:

Naruta, Yoshinori

Uno, Hidemitsu

Maruyama, Kazuhiro

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Article abstract of DOI:10.1246/cl.1982.609

The new total synthesis of pyranonaphthoquinone antibiotics, (+/-)-nanaomycin A (1) and (+/-)-deoxyfrenolicin (2), is discussed.The key step in the reaction sequence is Lewis acid mediated Michael addition of acylnaphthoquinone (5) with methyl 2-(dimethylphenylsilyl)-3-butenoate (7).

Full text of DOI:10.1246/cl.1982.609

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