Journal of Organic Chemistry p. 3072 - 3077 (1980)
Update date:2022-08-04
Topics:
Foster, Robert H.
Leonard, Nelson J.
Pyrazolo<3.4-f>quinazolin-9-one (prox-benzoisoallopurinol, 1), an extented analogue of 7-hydroxypyrazolo<4,3-d>pyrimidine (isoallopurinol, 2) and a potential dimensional probe for substrates of xanthine oxidase, has been synthesized by two independent routes.The title compound, prepared by elaboration of either a suitably substituted indazole or a quinazolinone, was found to be an active substrate for and an alternative-substrate inhibitor of xanthine oxidase.The product of enzymatic oxidation of prox-benzoisoallopurinol has been identified as the corresponding prox-benzoisoalloxanthine.
View MoreXuzhou Tianrun Chemical Co.,Ltd
website:http://www.tianrunchem.cn
Contact:86-516-83832636
Address:fuxing road
Shanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.
Contact:+86-21-51320130-801, 816
Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai
Jiaxing Taixin Pharmaceutical Chemical Co., Ltd
Contact:0573-82613601
Address:Chemical Park, Jiaxing, Zhejiang, China
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.
website:http://www.zyterpharm.com
Contact:+86-18858184290
Address:West Wenyi Road, Cangqian, Yuhang
Beyond Pharmaceutical Co., Ltd
Contact:+86-571-8195-3185
Address:No. 13-1, Liansheng Road, Yuhang District
Doi:10.1021/ja00538a014
(1980)Doi:10.1021/jo01305a018
(1980)Doi:10.1021/jo01306a019
(1980)Doi:10.1021/ja01550a074
(1958)Doi:10.1016/j.bmc.2004.05.033
(2004)Doi:10.1021/ol049261u
(2004)
