Synthesis and anticonvulsant activity of N-(benzoylalkyl)imidazoles and N-(ω-phenyl-ω-hydroxyalkyl)imidazoles

DOI: 10.1021/jm00138a017

Source and publish data:

Journal of Medicinal Chemistry p. 727 - 731 (1981)

Update date:2022-08-04

Topics:

Authors:

Nardi Nardi

Tajana Tajana

Leonardi

Pennini Pennini

Portioli

Magistretti

Subissi Subissi

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Article abstract of DOI:10.1021/jm00138a017

A novel series of N-(benzoylalkyl)imidazoles and N-(ω-phenyl-ω-hydroxyalkyl)imidazoles was synthesized and evaluated for anticonvulsant activity in mice against maximal electroshock induced seizures. Some of the compounds showed an activity comparable to or better than phenytoin and phenobarbital. The N-[β-[4-(β-phenylethyl)phenyl]-β-hydroxyethyl]imidazole (38) was selected for further studies; preclinical toxicology and additional efficacy evaluations are in progress. Structure-activity relationships are discussed.

Full text of DOI:10.1021/jm00138a017

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