Journal of the Chemical Society. Perkin transactions I p. 290 - 294 (1981)
Update date:2022-09-26
Topics: Heterocyclic compounds Intramolecular Substitution Aromatic nucleophilic Indole derivatives
Kametani, Tetsuji
Ohsawa, Tatsushi
Ihara, Masataka
Cyclisation of N-(2-bromo-4,5-dimethoxyphenethyl)acetamide (6) afforded 1-acetyl-2,3-dihydro-5,6-dimethoxy-1H-indole (13) by intramolecular nucleophilic aromatic substitution using sodium hydride and cuprous halide in dimethylformamide.The dihydroindoles (14), (15), and (16) were also synthesised from the corresponding amides (8) and (10) and the carbamate (12) in a similar manner.The dihydroindoles (13), (14), and (16) were converted into the indoles (20) and (21) in excellent yield by oxidation and subsequent alkaline hydrolysis.The 2-oxindoles (26) and (27) were also prepared under similar reaction condition from the phenylacetamide (24) and (25).
View MoreContact:+86-533-3112891
Address:zibo
Shanghai Dianyang Industry Co.,ltd
Contact:+86 21 6492 4669
Address:Chejing RD, Songjiang District, Shanghai, China
Synchem Pharma Co.,Ltd(expird)
Contact:+0086-21-61984905-1
Address:Building 60,Zimian Park, LongYang industrial Area, 1515Nong，Yuandong Road Fengxian District, Shanghai ,China
Hangzhou Sartort Biopharma Co., Ltd
website:http://www.sartort.com
Contact:86-571-87039693
Address:No. 57, Tech Park Road, Hangzhou, Zhejiang, China
Jinan Hongfangde Pharmatech Co.LTD
Contact:0531-88870908
Address:F Bldg,750#,Shunhua Rd,New&High-tech Zone,Jinan,Shandong,China 250101
Doi:10.1002/jccs.199800092
(1998)Doi:10.1021/ja01636a051
(1954)Doi:10.1016/j.bmcl.2004.05.044
(2004)Doi:10.1016/S0040-4039(00)92793-X
(1980)Doi:10.1007/BF00957722
(1982)Doi:10.1039/b405015k
(2004)
