Journal of Pharmaceutical Sciences p. 164 - 167 (1980)
Update date:2022-07-30
Topics:
Casalini
Mascellani
Tamagnone
Cesarano
Giumanini
The in vivo metabolism of 2-ethyl-2,3-dihydro-5-benzofuranacetic acid (furofenac), a new drug, was studied in rats, dogs, and humans. The drug has antiplatelet-aggregation activity and anti-inflammatory activity combined with low ulcerogenic power. Hydroxylated derivatives and analogous compounds were prepared, and their syntheses and chemical characteristics are described. TLC, GLC, high-pressure liquid chromatography, and GLC-mass spectrometry were applied to urine extracts, and authentic synthetic specimens were used for comparison. The products identified in human and dog urine were mainly conjugation compounds of the drug, while the products in rat urine were hydroxylated derivatives. Some pharmacological characteristics of the metabolites are discussed.
View MoreSichuan Sangao Biochemical Co., Ltd
Contact:+86-28-84874233
Address:19F, Bldg.2, Shudu Center, Tianfu 2nd St., Hi-tech zone, Chengdu 610041, Sichuan Province, China.
Shandong Jincheng Zhonghua Bio-pharmaceutical Co.,Ltd
Contact:+86-533-5415882
Address:Zichuan Economic Development Zone,Zibo City,Shandong Province,China
Angelisun(Chongqing) Pharmaceutical Co., LTD.
Contact:+86-23-68030926-816
Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China
Hebei DaPeng Pharm & Chem Co., Ltd.
Contact:86-317-7298678,0576-88861898 88861908
Address:West Songmen Village, East Songmen Town, Wuqiao, Cangzhou, Hebei ,China
Chengdu Boon Stream Chemical Industry Co.,Ltd.
Contact:+86-28-83156758
Address:No.859,Dongzikou Road,Jinniu District,Chengdu,Sichuan,P.R.China
Doi:10.1016/S0040-4039(00)71418-3
(1980)Doi:10.1039/b307378e
(2003)Doi:10.1021/jo016398e
(2002)Doi:10.1248/cpb.28.500
(1980)Doi:10.1039/d0sc04136j
(2020)Doi:10.1016/0040-4020(80)85030-7
(1980)
