Journal of Pharmaceutical Sciences p. 164 - 167 (1980)
Update date:2022-07-30
Topics:
Casalini
Mascellani
Tamagnone
Cesarano
Giumanini
The in vivo metabolism of 2-ethyl-2,3-dihydro-5-benzofuranacetic acid (furofenac), a new drug, was studied in rats, dogs, and humans. The drug has antiplatelet-aggregation activity and anti-inflammatory activity combined with low ulcerogenic power. Hydroxylated derivatives and analogous compounds were prepared, and their syntheses and chemical characteristics are described. TLC, GLC, high-pressure liquid chromatography, and GLC-mass spectrometry were applied to urine extracts, and authentic synthetic specimens were used for comparison. The products identified in human and dog urine were mainly conjugation compounds of the drug, while the products in rat urine were hydroxylated derivatives. Some pharmacological characteristics of the metabolites are discussed.
View MoreLuojiang Chenming Biological Products Co
Contact:+86 15000297032
Address:GROUP NO.4, HE SHENG VILLAGE, PANLONG TOWN,
Jinan YouCheng Pharmatech Co.,Ltd
Contact:+86-18653163205
Address:No.750, Shunhua Road, University Science Park, High-tech Zone, Jinan City
Puyang Huicheng Electronic Material Co., Ltd
website:http://huichengchem.weba.testwebsite.cn/index_en.html
Contact:+86-393-8910800
Address:West Section Shengli Road, Puyang457000, China
Contact:86-571-86737118-8689
Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
Shanghai Haoyuan Chemexpress Co., Ltd.
website:https://www.chemexpress.com/
Contact:86-21-58950125
Address:No.3 Building, No.1999, Zhangheng Road, ZhangjiangHighTech Park, Shanghai, P.R.China,201203
Doi:10.1016/S0040-4039(00)71418-3
(1980)Doi:10.1039/b307378e
(2003)Doi:10.1021/jo016398e
(2002)Doi:10.1248/cpb.28.500
(1980)Doi:10.1039/d0sc04136j
(2020)Doi:10.1016/0040-4020(80)85030-7
(1980)
