Improved Deprotection in Solid Phase Peptide Synthesis: Deprotection of Ni-Formyl-tryptophan to Tryptophan in Low Concentrations of HF in Me2S-p-Thiocresol Mixtures

Article abstract of DOI:10.1039/c39820000896

The Nⁱ-formyl protecting group of tryptophan in solid phase peptide synthesis was found to be removed efficiently and quantitatively by a new reagent, HF-Me2S-p-thiocresol-p-cresol (25:65:5:5, v/v/v/v) without detectable side reaction.